Masses of research have revealed that SFN upregulated both expression and stabilization of NRF2 primarily through its role as a DNMT inhibitor (Su et al., 2018b), exerting powerful anti-cancer effect in the esophageal cancer (Lu et al., 2021), breast cancer (Myzak et al., 2006) and cervical cancer (Myzak et al., 2006). The gene discussed is NFE2L2; the disease is breast carcinoma.