KEAP1 and cancer: According to previous research, numbers of chemopreventive compounds could affect histone acetylation mainly by regulating the activation or expression of HDACs involved in chromatin remodeling, gene expression and NRF2/KEAP1 signaling (Jabbarzadeh Kaboli et al., 2020), among which SFN could effectively inhibit various sorts of HDAC, which was commonly accompanied with decreased DNMTs, to induce autophagy, apoptosis and cell cycle alterations in different cancers.