Other than these, diverse cancer chemopreventive agents like pelargonidin (Li et al., 2019), taxifolin (TAX) (Kuang et al., 2017) and Ursolic acid (UA) (Kim et al., 2016) have been proven to epigenetically diminish HDACs and reactivate NRF2/KEAP1 pathway to exert anticancer effects in the mouse skin JB6 P+ cells, while CRA in NSCLC (Jin et al., 2021) and LUT in colorectal cancer (Zuo et al., 2018) have been observed to target the same signal pathway, subsequently inducing downstream target genes with respect to cell cycle arrest, autophagy and apoptosis in cancer cells. The gene discussed is KEAP1; the disease is cancer.