KEAP1 and ovarian cancer: In addition, it has been confirmed that miR-200a-3p/141-3p directly combined to 3′-UTR of KEAP1, thus profoundly dysregulating NRF2/KEAP1 pathway in renal tumorigenesis and ovarian cancer cells, which could be blocked by PEITC significantly to reduce the oxidative stress response (Mateescu et al., 2011; Lan, 2012; Jiang et al., 2013; Cortez et al., 2014).