In breast cancer model, miR-93 could decrease NRF2 expression at mRNA and protein levels (Singh et al., 2013) to impair its downstream genes such as NQO1 and SOD3 (Singh and Bhat, 2012; Singh et al., 2012), thus playing a crucial role in regulating apoptosis and oxidative DNA damage in cancer cells. This evidence concerns the gene NFE2L2 and cancer.