For example, miR-200a stimulates the NRF2/KEAP1 signaling by suppressing KEAP1 to decrease ROS concentration in breast cancer cells (Cloer et al., 2019; Bono et al., 2021), while a few identified miRNAs including miR144/153/27a/142-5p directly modulate NRF2 dependent redox homeostasis by suppressing NRF2 gene expression in neuronal cells (Narasimhan et al., 2012). This evidence concerns the gene NFE2L2 and breast cancer.