KEAP1 and hepatocellular carcinoma: Contrary to 5-aza, Fumonisin B, a common toxic mycotoxins of cereal grains, activated NRF2/KEAP1 pathway by hypermethylating CpG islands in KEAP1 gene, consequently enhancing ROS production along with promoting cell membrane damage in human hepatoma cells (Arumugam et al., 2021).