NFE2L2 and hepatocellular carcinoma: In hepatocellular carcinoma, accumulating evidence indicated that Apigenin negatively regulated the protein level of NRF2 through inducing miR-101, which could directly target the 3′-UTR of NRF2 (Gao et al., 2017) to ultimately suppress cancer apoptosis and oxidative damage (Liu et al., 2016).