The relationship between extracellular nucleotides (ATP and AMP) and CRC has already been described in previous studies, but the roles of ATPase and AMPase in CRC have not been thoroughly studied.Therefore, the present study aimed to determine ATPase and AMPase activity in the serum of patients with CRC and the clinical value of these enzymes combined with tumor biomarkers in the diagnosis of CRC. Here, DNAH8 is linked to colorectal carcinoma.