EXTL2 and asthma: Specifically, the T allele of rs12091010, located at 6 kb downstream of the 3′ UTR of VCAM1 and 150 kb upstream of the transcription start site of EXTL2, was associated with lower odds of having asthma exacerbations and decreased EXTL2 expression31 The T allele is more common among Latinos/Admixed Americans, followed by Europeans, Africans, and East Asians (Figure S6).