APOE and cardiovascular disorder: For example, the role of Apolipoprotein E in lipid metabolism has been well established (Dose et al., 2016; Mahley, 2016), APOE was also reported to be associated with the risk of cardiovascular diseases and diabetes mellitus (Eichner et al., 2002), and APOE is the most replicated longevity‐related gene (Broer et al., 2015; Deelen et al., 2014; Deelen et al., 2019; Joshi et al., 2017; Nebel et al., 2011; Sebastiani et al., 2017).