Although the mechanisms by which the CC genotype of rs12608932 in UNC13A significantly decreased the survival time of ALS patients was not entirely clear, the very recent studies found UNC13A variants exacerbate the effects of reduced TDP-43 function and TDP-43 can repress a cryptic exon-splicing event in UNC13A [127, 128]. This evidence concerns the gene UNC13A and amyotrophic lateral sclerosis.