Using NMA and pairwise meta-analysis, we found three genes, including ATXN2 polyQ, C9orf72 repeats, and FUS variants, and two genetic modifiers, ZNF521B rs2275294 C allele and UNC13A rs12608932 CC genotype, were associated with short survival of ALS. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.