Further, Fraticelli et al. compared 4 different schemes of treatment in patients with GDM, 400 mcg of folic acid alone, 4000 mg of myoinositol combined with 400 mcg of folic acid, 500 mg of d-chiro-inositol combined with 400 mcg of folic acid and 1100/27.6 mg myo/d-chiro-inositol plus 400 mcg folic acid in a total of 80 patients, showing that women treated with myoinositol had a decrease in HOMA-IR, a lower need for insulin treatment and lower birth weight [27]. Here, INS is linked to gestational diabetes.