To evaluate the in vivo anti-tumor efficacy of HSP90 inhibitors in a mouse model using PRCC xenografts, NSG mice were injected subcutaneously either with UOK345 (MET mutation) or with UOK342 (copy number gain of wild type MET) and treated with SNX5422 (30 mg/kg) 3 times a week until five weeks once tumors were established (100 mm3) as depicted in Fig. 6A. SNX2112 is the active inhibitor but SNX 5422 is a prodrug that is orally available and used in animal studies [19, 25, 26]. The gene discussed is MET; the disease is neoplasm.