In order to determine the biologic relevance of the genes in PRCC that were modulated by SNX2112, likely due to the downstream consequences of degradation of HSP90 clients, we explored the TCGA dataset from the Kidney Renal Papillary Cell Carcinoma (KIRP) cohort to ascertain whether any of the top 200 (100 up and down) differentially expressed genes identified by RNA seq analysis (Suppl. Here, PRCC is linked to papillary renal cell carcinoma.