AKT1 and neoplasm: Further, SNX5422 also induced the degradation of MET and inhibits key downstream mediators of MET activity including activated forms of MET(Y1234/1235), AKT (Ser473) and ERK (Thr202/Tyr 204) in tumor-bearing xenografts (n = 3, each group) as demonstrated by western blotting (Fig. 6F).