POU2AF1 is expressed in a highly cell-specific manner, being most abundant in B cells.49 The protective allele rs4529910-G has been reported to decrease POU2AF1 expression levels in B cells.31 Therefore, we think that rs4529910-G has a protective effect for autoimmune and allergic diseases by attenuating humoral immunity. Here, POU2AF1 is linked to allergic disease.