Our study newly identified six loci associated with allergic diseases (MIIP, CXCR4, SCML4, CYP1B1, ICOS and LINC00824) and four pleiotropic loci associated with both autoimmune and allergic diseases (PRDM2, G3BP1, HBS1L and POU2AF1). The gene discussed is POU2AF1; the disease is allergic disease.