STING1 and autoimmune disease: G3BP1 plays a positive role in activating the STING pathway, resulting in type 1 interferon response.48G3BP1 expression levels have been reported to be high in autoimmune diseases involved in type 1 interferon, such as RA, myositis and SLE.31 Because rs2053062-T has been reported to decrease G3BP1 expression levels, this variant may have a protective effect on disease susceptibility by suppressing type 1 interferon activation.