We identified with BLAC a number of putative driver genes on the X chromosome such as DMD, RSK4, AFF2, ODF1, etc. A cumulative score was developed combining mutation level information at the patient level which showed promise in survival risk stratification in bladder urothelial carcinoma (BLCA), lung adenocarcinoma (LUAD), and hepatocellular carcinoma (HCC). This evidence concerns the gene RPS6KA6 and bladder transitional cell carcinoma.