FUS and amyotrophic lateral sclerosis: This contrasts with our present results that phosphorylation by CK1δ or CK1ε increased the solubility of FUS in HEK293 cells (Fig. 3), and that coexpression of human CK1δ or Dco with FUS in the photoreceptor neurons ameliorated the toxicity induced by the expression of wt or P525L ALS-mutant FUS (Figs. 5, and 6).