Previous studies revealed that phosphoinositide 3-kinase–like kinase family kinases, for example, DNA-PK and ataxia–telangiectasia mutated, phosphorylate the S/T-Q motif in the LC domain of FUS (Fig. 1D) (26, 31, 32). The gene discussed is PRKDC; the disease is Ataxia-telangiectasia.