In 2019, Lu et al. conducted a further study on the relationship between MSCs, hepatocyte growth factor (HGF) and DCregs and concluded that MSCs alleviate early ALI by inducing mature dendritic cells (MDCs) to differentiate into regulatory dendritic cells (DCs) through paracrine hepatocyte growth factor (HGF), and the mechanism of HGF-induced differentiation of mDCs into tolerogenic dendritic cells (DCregs) is related to the activation of the Akt pathway [14]. This evidence concerns the gene HGF and acute respiratory distress syndrome.