TNFRSF8 and peripheral T-cell lymphoma, not otherwise specified: The anti-CD30 drug conjugate Brentuximab vedotin (BV) was approved in 2018 for previously untreated CD30 + peripheral T-cell lymphomas after ECHELON-2, a multi-center randomized phase 3 study of BV-CHP, established the benefit of adding targeted CD30 + therapy.