As recently described [50], a pilot high-throughput genotyping experiment was performed using the Human Immunochip® (coated with > 196 K markers, Illumina®, San Diego, CA, USA) in a subset of children representing “polarized extremes” of severe and non-severe malaria: cases (SMA with Hb < 5.0 g/dL, n = 70) vs. controls (non-SMA with Hb > 8.0 g/dL, n = 74). This evidence concerns the gene GSTM1 and malaria.