LOXL2 and neoplasm: For non-neoplastic diseases, EV contents also exert important regulatory roles as they mediate EC function, with miR-125a [53], miR-210 [54], miR-375 [55], miR-214 [56], lysyl oxidase like-2 (LOXL2) [57], and HSP70 [58] having significant roles in this process.