Based on the findings of the present study, although the administration of the E7 DNA vaccine or IL-24 alone was not effective in reducing the tumor volume, the adjuvant effect of IL-24 on the E7 DNA vaccine induced a significant reduction in the tumor volume and a high anti-tumor effect, in comparison to the administration of the vaccine alone, was observed, especially from week 4 on. The gene discussed is IL24; the disease is neoplasm.