There are a broad range of mechanisms through which MDA-7/IL-24 acts as a powerful anti-cancer agent, including the inducement of apoptosis and autophagy, the regulation of angiogenesis, invasion and metastasis, the propagation of anti-cancer responses to nearby malignant cells through bystander effect, as well as the enhancement of anti-cancer function of other therapeutic methods as a synergistic agent [12]. The gene discussed is IL24; the disease is cancer.