An RT-qPCR test revealed that expression levels of IL-5, POSTN, and IL-33 mRNA were higher in NP tissue from CRSwNP patients than in sinonasal mucosal tissues obtained from CRSsNP., Hence, blood samples from patients with CRSwNP were used for protein studies. This evidence concerns the gene IL33 and chronic rhinosinusitis without nasal polyps.