The mRNA expression of IL-5, POSTN, and IL-33 in sinonasal mucosa tissues from CRSsNP and CRSwNP (n = 53 and n = 40) or in NP tissue of CRSwNP (n = 40) patients was determined by RT-qPCR. This evidence concerns the gene IL5 and chronic rhinosinusitis without nasal polyps.