Mean serum IgE content in control subjects was 49.02 ± 10.82, in CRSsNP patients was 158.86 ± 25.42 (50.08 ± 11.23 and 409.44 ± 56.93 in nonalergy and allergy subjects, respectively), in CRSwNP patients was 166.05 ± 61.22 (50.75 ± 12.33 and 654.12 ± 65.45 in nonalergy and allergy subjects, respectively). The gene discussed is IGHE; the disease is chronic rhinosinusitis without nasal polyps.