An RT-qPCR test revealed that expression levels of IL-5, POSTN, and IL-33 mRNA were higher in NP tissue from CRSwNP patients than in sinonasal mucosal tissues obtained from CRSsNP., Hence, blood samples from patients with CRSwNP were used for protein studies. The gene discussed is IL33; the disease is chronic rhinosinusitis with nasal polyps.