Data showed that history of cardiac surgery (P = 0.005, OR = 2.522) and critical respiratory disease (P = 0.005, OR = 2.905), high CRUSADE risk stratification (P = 0.018, OR = 1.592), and administration of bivalirudin combined with GP IIb/IIIa inhibitors (P < 0.001, OR = 4.958) were independent factors for higher incidence of AEs; while elective operation (P < 0.001, OR = 0.369) was an independent factor for lower incidence of AEs (Fig. 2A). This evidence concerns the gene ITGA2B and respiratory system disorder.