Concerning thrombocytopenia, history of cardiac surgery (P = 0.001, OR = 5.826), elective operation (P = 0.035, OR = 2.486) and administration of bivalirudin combined with GP IIb/IIIa inhibitors (P = 0.033, OR = 9.033) were independent risk factors for thrombocytopenia. The gene discussed is ITGA2B; the disease is Thrombocytopenia.