Conventional administration of antihypertensive agents, such as Angiotensin Receptor Blockers or Angiotensin-Converting Enzyme Inhibitors, positively alter the Angiotensin-Converting Enzyme 2 (ACE2) expression, making it easier for SARS-CoV-2 to infiltrate pneumocytes and ultimately deteriorating the severity and mortality of the infection. The gene discussed is ACE2; the disease is infection.