In addition, recent experimental studies have shown that large amounts of estrogen in premenopausal women can promote β-oxidation of free fatty acids in the liver, regulate energy homeostasis in the body, inhibit adipose tissue breakdown, and enhance adipose tissue insulin sensitivity, reducing peripheral delivery of free fatty acids to the liver, thereby exerting an anti-hepatic steatosis effect [46]. The gene discussed is INS; the disease is Hepatic steatosis.