We therefore also measured ANG levels in the plasma of this cohort of patients and found that plasma ANG amount was 475.1 ± 8.6 ng/ml in prostate cancer patients, higher than that in control subjects (379.3 ± 6.3 ng/ml, p < 0.0001) (Supplementary Fig. 3a). This evidence concerns the gene ANG and prostate carcinoma.