Plasma RNASE4 levels in patients with less differentiated cancer tissues, such as tumors with biopsy grade 7 (n = 26, 164.1 ± 3.9 ng/ml, p = 0.03) or surgical Gleason 7 (n = 32, 157.8 ± 3.3 ng/ml, p = 0.05), were higher than in those with well differentiated cancer tissues, such as tumors with biopsy grade 6 (n = 89, 149.0 ± 2.8 ng/ml) or surgical Gleason 6 (n = 84, 147.8 ± 3.1 ng/ml) (Fig. 2c and d). This evidence concerns the gene RNASE4 and cancer.