In this cohort, PSA level in the plasma was also higher in prostate cancer patients (5.4 ± 0.2 ng/ml) compared to control subjects (1.0 ± 0.1 ng/ml) (p < 0.0001) and showed an AUC of 0.98 (0.96–1.00) and a diagnostic accuracy of 93% (Fig. 1c and d). This evidence concerns the gene KLK3 and Familial prostate cancer.