Our results demonstrate that CHIP is not prevalent in the setting of premature aging that characterizes HGPS and, therefore, is unlikely to contribute to the accelerated aging phenotype characterized by an increased cardiovascular risk that is observed in patients affected by this progeroid syndrome, in contrast to its emerging role as a potent cardiovascular risk factor in the general population [3, 6]. The gene discussed is STUB1; the disease is Hutchinson-Gilford progeria syndrome.