STUB1 and Hutchinson-Gilford progeria syndrome: In a broader context, our findings may reflect that somatic mutagenesis in the hematopoietic system is uncommon at young ages, even in a setting of genomic instability like HGPS, and/or that the progerin-induced senescent phenotype in HGPS patients’ cells [15] may prevent the expansion of hematopoietic clones that acquire CHIP mutations.