LMNA and Hutchinson-Gilford progeria syndrome: Hutchinson-Gilford progeria syndrome (HGPS) is an ultra-rare genetic disease caused by a heterozygous de novo point mutation in the LMNA gene (c.1824C > T/p.G608G in most patients) that provokes the production and accumulation of a truncated form of the prelamin A protein called progerin [15].