In a study that examined the association between obesity and DNA methylation in NHB and NHW women diagnosed with breast cancer, the authors detected interactions with ER status (PSMB1, QSOX1, and PHF1) and race (TOMM20) among the top 20 obesity-associated CpG cites. The gene discussed is ESR1; the disease is obesity due to melanocortin 4 receptor deficiency.