Also, many genes encoding chemokines, cytokines and chemokine receptors, which are involved in neuroinflammatory processes in ischemic stroke, were regulated, including Cxcr2 [47] in endothelial cells, Ccl5 [34], Il11 and Il6 [117] in pericytes, Lcn2 [57] in astrocytes [124] and pericytes, and Il1rn [126] in microglia. Here, LCN2 is linked to ischemic stroke.