Multivariable linear regression analysis was performed for identifying independent factors associated with changes in MMSE using parameters with p < 0.05 (changes in BMI, cerebral rSO2, and serum albumin level), and the following confounding factors: changes in eGFR, hemoglobin, proteinuria, salt intake, and energy intake, age, presence of DM, history of comorbid cerebrovascular disease, and use of renin–angiotensin system blocker. This evidence concerns the gene REN and cerebrovascular disorder.