REN and diabetes mellitus: Multivariable linear regression analysis was performed for identifying independent factors associated with changes in MMSE using parameters with p < 0.05 (changes in BMI, cerebral rSO2, and serum albumin level), and the following confounding factors: changes in eGFR, hemoglobin, proteinuria, salt intake, and energy intake, age, presence of DM, history of comorbid cerebrovascular disease, and use of renin–angiotensin system blocker.