Transcriptomic profiling of infected LT-HSC and cross-species systems biology analysis of large publicly available datasets revealed a unique Leishmania-triggered gene signature in LT-HSC, StemLeish, containing several host genes not previously associated with either experimental or human leishmaniasis (Rgs1, Twistnb, Ell2, and Vav1). The gene discussed is POLR1F; the disease is leishmaniasis.