ISL1 and coronary artery calcification: Therefore, plasma miRNA-204 level can be used as a predictor to evaluate coronary artery calcification severity.135 However, Wang et al.136 reported that miRNA-128‐3p promoted Wnt‐1, β‐catenin, GSK‐3β, and Bax expression by downregulating Islet1 (ISL1) through activation of the Wnt pathway, thereby exacerbating cardiovascular calcification in type 2 diabetic rats.136 Chen et al.137 showed that miRNA-19A-3p inhibited HDAC4 expression, upregulated Runx2 and osteocalcin levels, and enhanced ALP activity by targeting the 3’UTR of HDAC4.