GPX1 and heart failure: Therefore, DNA methylation can reveal the pathogenesis and process of CCC by regulating CCC-related cardiac and immune system genes expression.77 In addition, Zhu et al.78 demonstrated that selenium supplementation could inhibit DNMT2-induced DNA methylation of glutathione peroxidase 1 gene promoter in cardiomyocytes, increased glutathione peroxidase 1 expression, further reduced intracellular reactive oxygen species production, and cardiomyocyte apoptosis, and thus played a protective role in heart failure.78