TGFB1 and Myocardial fibrosis: Furthermore, reduced cirRNA 010567 expression alleviates myocardial fibrosis by blocking the TGFβ1 signaling pathway, thereby improving cardiac function.202 Circ_LAS1L inhibits cardiac fibroblasts proliferation by increasing the expression of SFRP5 through sponge miRNA-125b.203 Therefore, cirRNA 010567 and circ_LAS1L slow the progression of heart failure by reducing myocardial fibrosis and preventing ventricular remodeling.