Thus it generates a protective effect on the heart.261 Morales et al262 demonstrated that inhibition of class I HDACs with apicidin induced the expression of the mTOR inhibitor tuberous sclerosis complex 2 (TSC2), which in turn attenuated cardiac hypertrophy by inhibiting mTOR.262 In addition, one study data suggest that resveratrol disminishes IL-6 activation induced by SIRT1 to protect H9c2 cells from Ang-II-induced hypertrophy.263. Here, SIRT1 is linked to cardiac hypertrophy.