Therefore, these differentially expressed methylated genes in heart failure may be a new markers for the detection and diagnosis of heart failure.76 A study on the effect of genome-wide cardiac DNA methylation on overall gene expression in myocardial samples from patients with end-stage chronic Chagas disease cardiomyopathy (CCC) showed that two differentially expressed methylated genes, KCNA4 and KCNIP4, were involved in the regulation of potassium channels. The gene discussed is KCNA3; the disease is heart failure.