KCNN3 and heart failure: CirRNAs are deemed as novel regulatory genes in cardiomyocyte hypertrophy, fibrosis, autophagy, and apoptosis, which are involved in the development of heart failure.199 Mmu_circ_0005019 regulates the expression of its target gene Kcnn3 by targeting miRNA-499-5p, thereby inhibiting cardiac fibrosis and reversing electrical remodeling of cardiac myocytes.200 In addition, circNfix inhibit the development of heart failure by regulating the proliferation of cardiomyocytes after myocardial infarction.