Therefore, these differentially expressed methylated genes in heart failure may be a new markers for the detection and diagnosis of heart failure.76 A study on the effect of genome-wide cardiac DNA methylation on overall gene expression in myocardial samples from patients with end-stage chronic Chagas disease cardiomyopathy (CCC) showed that two differentially expressed methylated genes, KCNA4 and KCNIP4, were involved in the regulation of potassium channels. Here, KCNA4 is linked to heart failure.