Intravenous administration of SNHG12 alleviated atherosclerosis by protecting the intima from DNA damage and slowing endothelial aging.288 Furthermore, volanesorsen was found to treat hypertriglyceridemia by targeting apolipoprotein C3(APOC3).289,290 IONIS-APO(a)-LRx was a novel, tolerable and effective therapy for reducing lipoprotein(a) (Lp[a]) concentration. Here, APOC3 is linked to atherosclerosis.