BRCA1 and cancer: After having demonstrated that BRCA-1 downregulation by ceapinA7 in combination with DPE or Thapsigargin was not due to a reduced mRNA expression and considering that BRCA-1 stability is strongly dependent on the expression of HSP90, being a client protein of this chaperone [19], we investigated the expression of HSP90 in cancer cells undergoing DPE or Thapsigargin treatments with or without ceapinA7.