As TLR4 is the essential trigger of host immunity against P. aeruginosa infection, its deficient mice show higher bacterial burdens and severe lung injury under infection.274 Nevertheless, the TLR4 pathway does not function alone and is very complex, which may be impacted or coregulated by a number of signaling systems including AnxA2,275 autophagy,276,277 inflammasome,278 cGAS,279,280 ion channel proteins,281 DNA repair proteins,282 miRNAs,40,266,283 and lncRNA,229 to name a few. The gene discussed is TLR4; the disease is infection.