Since even relatively mild CKD increases the risk of CAVS (Vavilis et al., 2019) and since valvular calcification is highly prevalent in CKD patients (Rattazzi et al., 2013), it is noteworthy that DDR2 expression decreased at an earlier stage of disease in valves from patients with CKD compared with normal renal function. This evidence concerns the gene DDR2 and chronic kidney disease.