Tyrosine kinase receptor amplifications are often identified in subtype CIN, and phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and AT-rich interaction domain 1A (ARID1A) gene mutations are enriched in subtype MSI and EBV positivity. This evidence concerns the gene PIK3CA and cervical squamous intraepithelial neoplasia.