A significant downregulation of RUNX-2 and COL1A1 osteogenic markers was observed in hPDLSCs exposed to ELF-EMF for 28 days compared to 10 days of exposure, both with and without OM, suggesting the ability of ELF-EMF to improve new bone formation early (Fig. 6a). The gene discussed is COL1A1; the disease is ocular melanoma.