For example, possible IM episodes should not necessarily be viewed as a sign of DEB onset: to be properly managed, these episodes need to be understood within the context in which they appear (e.g., potential significant/stressful emotional events occurring within the relational/familial context), and other possible reasons for why individuals reduce or omit insulin (e.g., fear of hypoglycemia, interference with activities of daily living, injection pain/embarrassment, etc.)need to be ruled out. This evidence concerns the gene INS and Hypoglycemia.