It was of great surprise when a large percentage of P. falciparum isolates collected in Peru from 2003 to 2008 lacked pfhrp2 and/or pfhrp3 (pfhrp2/3), where HRP2-RDT use was basically non-existent [14].This high prevalence of gene deletions led the WHO to recommend using tests targeting alternative antigens or quality microscopy for malaria diagnosis in Peru, and to urgently map gene deleted parasites in neighboring countries and others outside South America [15]. This evidence concerns the gene HDGFL2 and malaria.