CDKN2C and cancer: Taking the current studies, we infer that: (1) the protective prognosis roles for some cancers (e.g., CESC and THYM) reflect the typical function of CDKN2C in suppressing tumors; (2) the mutational CDKN2C can promote cancer based on cell and mice experiments [8, 48, 49], which may be the reason for patients with elevated CDKN2C expression have poor prognosis in most cancers investigated in our study.