According to the stromal, immune, and ESTIMATE scores (Fig. 9A and Additional file 9), CDKN2C expression was positively relevant to the immune microenvironment in TGCT (testicular germ cell tumor) and PRAD (all Spearman ρ > 0.25, p < 0.05) and negatively associated with the immune microenvironment in GBM and sarcoma (all Spearman ρ < –0.25, p < 0.05) (Fig. 9A). This evidence concerns the gene CDKN2C and glioblastoma.