It has been found that Piezo1, which exists on endothelial cells, can be activated at the turning point of the aortic inner wall, where the blood flow shear force changes the most, and activate integrin α6 and FAK in a Piezo-Gq/G11-dependent manner, It further promotes the activation of NF-κB pathway and promotes the occurrence of atherosclerosis. Here, PIEZO1 is linked to atherosclerosis.