The addition of NT-proBNP concentrations and LVEF levels to the base model also improved reclassification by 22.9% (95% CI 10.5–34.4%) for patients who developed postoperative AKI and by 36.3% (95% CI 29.5–43.9%) for those who did not, resulting in a significant overall improvement in net reclassification (NRI 0.591 95% CI 0.437, 0.752, P < 0.001). The gene discussed is NPPB; the disease is acute kidney injury.