Among them, the 5-gene set of ZPBP, GOT1L1, ACTRT2, SPATA45 and TOPAZ1 (all restricted to male germ cells) was identified as an optimal classifier for prognostic stratification in T-ALL patients (p < 10–4 for OS and p < 10–5 for EFS). This evidence concerns the gene ZPBP and acute lymphoblastic leukemia.