Many RNA-binding proteins, such as fused in sarcoma (FUS), tau, alpha synuclein (α-Syn), and TAR DNA-binding protein 43 (TDP-43), are the main components of protein inclusions or aggregates in diverse neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) [144], frontotemporal dementia (FTD) [144, 145], Parkinson’s disease (PD)[146], and AD [147]. Here, TARDBP is linked to Alzheimer disease.