High PSMD14 mRNA and protein expression was associated with a worse prognosis in several cancers, including HNSCC (Jing et al. 2021a; Lv et al. 2019; Wang et al. 2019; Zhu et al. 2018; Luo et al. 2017; Song et al. 2017; Zhang et al. 2020; Lei et al. 2021). This evidence concerns the gene PSMD14 and head and neck squamous cell carcinoma.