PTGS2 and Wilson disease: Given that PTGDS was upregulated in DRG sensory neurons of mice WD-fed, we then sought to determine the concentration of PGD2 in the spinal cord (SC) and DRG of WD and NC-fed mice, where prostaglandins and prostaglandin mediators of synthesis such as COX-2 are predominantly expressed in murine models of inflammation18.