Dopamine agonists (such as pramipexole)85,108–110, monoamine oxidase B (MAOB) inhibitors (such as selegiline, rasagiline)111–113, and catechol-O-methyltransferase (COMT) inhibitors (such as entacapone, tolcapone)85,114 were also reported to alleviate tremor via different mechanisms. This evidence concerns the gene COMT and Tremor.