Univariate analysis showed that the TRAIL level was related to the disease burden (P = 0.037), IL-2 was related to the infused dose of CAR-T cells (P = 0.002), and TNF-α, IL-6, IL-10, IFN-γ, IL-2, GM-CSF, and granzyme B were related to severe manifestations of CRS (P = 0.003, P = 0.001, P = 0.019, P = 0.002, P = 0.009, P = 0.005, and P = 0.015, respectively). The gene discussed is IL2; the disease is congenital rubella syndrome.