Multiple histone demethylases, such as LSD1 (also known as KDM1A), are overexpressed in patients with advanced PCa.411 LSD1 demethylates H3K4me1 and H3K4me2.412 LSD1 co-operates with AR and activates AR-dependent transcription or a subset of cell-cycle gene expression.413,414 A clinical trial with a novel LSD1 inhibitor CC-90011 was recently launched (Table 9).415. Here, AR is linked to posterior cortical atrophy.