Cytosolic calcium (Ca2+) signaling plays an important role in the bone metastasis of PCa.219 Elevated Ca2+ stimulates PTHrP secretion and activates RANKL/RANK signaling in osteoclasts, which promotes bone resorption and calcium release, in turn promoting tumor cell proliferation and maintaining PCa cell homing to bone.219 Targeting calcium signaling could be a promising strategy for managing PCa bone metastasis. This evidence concerns the gene PTHLH and posterior cortical atrophy.