Fibroblast growth factor (FGF) receptors (FGFR1/4) and their ligands (FGF1/2/4/8/17) are overexpressed in PCa.501–504 Enhanced FGF signaling leads to tumor progression, angiogenesis, epithelial-to-mesenchymal transition (EMT), and upregulation of AR.505–507 Moreover, FGF/FGFR activation is highly correlated with AR-null PCa and drug resistance.508 Therefore, inhibition of the FGF axis may be a viable strategy for the treatment of PCa. Here, FGFR1 is linked to posterior cortical atrophy.