The vast majority of human genes (>95%) are alternatively spliced by the spliceosome, which enables genes to express splice isoforms that often exhibit distinctive functions.75,536 Alternative splicing affects genes (such as FGFR, ERG, VEGFA, and AR) that are clearly linked to the etiology of PCa, allowing us to develop novel targeted therapies that modulate alternative splicing for the treatment of PCa. The gene discussed is ERG; the disease is posterior cortical atrophy.