TP53 and posterior cortical atrophy: The tumor suppressor p53 is widely known as the “genome guardian.” Activated p53 binds to a specific DNA sequence as a tetramer to promote gene expression (such as CDKN1A, BAX, PUMA, and NOXA), thus inducing cell apoptosis and cell-cycle arrest.364 The TP53 gene, which encodes the p53 protein, is frequently mutated in PCa, especially in neuroendocrine-like mCRPC.