AD pathophysiology also includes neuroinflammation, which is associated with elevation of pro-inflammatory factors such as tumor necrosis factor alpha α (TNF-α), interleukin 1β (IL-1β), interleukin 6 (IL-6), and other cytokines population (Italiani et al., 2018; Zhao et al., 2003; Zuliani et al., 2007). This evidence concerns the gene TNF and Alzheimer disease.