TNF and Alzheimer disease: To elucidate a potential role of neuroinflammation, we examined the effect of pro-inflammatory cytokines on thiamin uptake by the SH-SY5Y cells, focusing on studying the effect of exposure to IL-1β, IL-6, and TNF-α on thiamin uptake physiology and molecular biology since levels of these pro-inflammatory cytokines have been shown to be elevated in brain regions and cerebrospinal fluid (CSF) of AD patients (Italiani et al., 2018; Veerhuis et al., 1999; Zhao et al., 2003; Zuliani et al., 2007).