The PINK1 (PTEN-induced putative kinase 1)−PARK2 pathway has also been proposed as a crucial mechanism for mitophagic degradation, and inhibition of PINK1−PARK2 pathway-mediated mitophagy results in elevated ROS generation and inflammasome activation in small airway epithelial cells from COPD patients [58]. Here, PINK1 is linked to chronic obstructive pulmonary disease.