Tissue specificity is an important aspect of many genetic diseases [40]; We therefore downloaded tissue-specific ChIP-Seq data in the form of processed peak calls for histone modifications (e.g. H3K27ac, H3K4me1, etc), CTCF binding sites, DNase hypersensitive sites, and ChromHMM predicted promoters and enhancers from the ENCODE project [19]. The gene discussed is CTCF; the disease is hereditary disease.