When the FIT cut-off was temporarily increased to 50, 55, 60 and 70 μg Hb/g faeces, respectively 400, 600, 700 and 900 (0.08%, 0.12%, 0.14%, 0.18%) more individuals would have died as a result of CRC from 2020 to 2050. This evidence concerns the gene GSTM1 and colorectal carcinoma.