A study by Yasari et al. involving adult rats with obesity, exercised for 8 weeks and then detrained for 6 weeks, showed that detraining completely reversed the effectiveness of exercise with rapid increases in intra-abdominal fat deposition, the diameter of adipocytes in the WAT, and activity of lipoprotein lipase to a level not different from that of age-matched sedentary rats [18]. Here, LPL is linked to obesity due to melanocortin 4 receptor deficiency.