Homozygotes for the P1104A polymorphism of TYK2 gene are at higher risk to develop clinical forms of tuberculosis, and Kerner et al. (2021) establish that, while the frequency of this pathogenic variant has fluctuated markedly over the last 10,000 years in Europe, it`s frequency has decreased dramatically after the Bronze Age [2]. Here, TYK2 is linked to tuberculosis.