CTCF and hepatocellular carcinoma: Further interrogation of the ENCODE data showed that, out of 28 cell lines profiled, the highest biochemical signals observed for all four enhancer signatures were identified in a commercially available human liver carcinoma cell line, HepG2 (z-scores: DNase, 3.19; H3K4me3, 4.05; H3K27ac, 3.08; CTCF, –10.00).